Phenytoin for neuroprotection
نویسندگان
چکیده
منابع مشابه
Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma.
PURPOSE Sustained influx of intracellular sodium through voltage-gated sodium channels is an important event in the cascade leading to degeneration of axons. This study tested the hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal ganglion cells (RGCs) and optic nerve axons in an experimental model of glaucoma. METHODS Chronic elevation of rat in...
متن کاملCharcoal hemoperfusion for phenytoin intoxication.
Accidental ingestion of phenytoin can lead to severe neurological sequelae. Charcoal hemoperfusion decreases phenytoin levels but has never been reported before in children. We present a child with accidental ingestion of phenytoin who responded to charcoal hemoperfusion.
متن کاملCurrent Practice of Phenytoin - Revisited Running title: Phenytoin revisited
Phenytoin is one the most widely used antiepileptic drug among other antiepileptic drugs and is one of the vital medication for basic health system. Phenytoin has been used not only for convulsive but also for nonconvulsive treatment like arrhythmia, trigeminal neuralgia, digoxin toxicity, wound healing and in other disease conditions. With the wide range of usage of phenytoin, it has a collect...
متن کاملPHENYTOIN AND THE REPRODUCTIVE SYSTEM
In order to evaluate the effects of phenytoin on the reproductive system of rats in detail, 60 male rats were divided equally into 6 groups: 1-5 received 10 mg/kg/day phenytoin IP for 1,2,3,4 and 5 weeks, respectively. However, group 5 did not receive any phenytoin for the last 5th week. The control group (group 6) did not receive any treatment. The results revealed that phenytoin does not ...
متن کاملMitochondrial approaches for neuroprotection.
A large body of evidence from postmortem brain tissue and genetic analysis in humans and biochemical and pathological studies in animal models (transgenic and toxin) of neurodegeneration suggest that mitochondrial dysfunction is a common pathological mechanism. Mitochondrial dysfunction from oxidative stress, mitochondrial DNA deletions, pathological mutations, altered mitochondrial morphology,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet Neurology
سال: 2016
ISSN: 1474-4422
DOI: 10.1016/s1474-4422(16)30096-5